Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Letter to Editor Volume 6 Issue 10

Tumour Budding - A Prognostic Indicator in Oral Squamous Cell Carcinoma?

Amith KP*, Gautam T, Deepa Kamath G and Shiva Bharani KSN

College of Dental Sciences and Hospital, Davanagere, India

*Corresponding Author: Amith KP, College of Dental Sciences and Hospital, Davanagere, India.

Received: August 29, 2022; Published: September 12, 2022

We read the article with interest the study by the author Yopovinu Rhusto., et al. This study has elucidated a statistically significant and clinically relevant association between POI, PNI with LNM and locoreginal recurrence. Other pathological features: along with pattern of invasion such as depth of invasion, grade of pathological differentiation and neuro - vascular invasion are usually considered for prognostication for disease [1-6].

Keywords: Tongue; Squamous Cell Carcinoma; Pattern of Invasion (POI); Worst Pattern of Invasion (WOPI) Perineural Invasion (PNI); Lymphnode Metastasis (LNM); Tumour Budding


  1. Wu, et al. “Can pattern and depth of invasion predict lymph node relapse and prognosis in tongue squamous cell carcinoma”. BMC Cancer 19 (2019): 714.
  2. Deval Parekh., et al. “Worst pattern of invasion - type 4 (wopi-4) and Lymphocyte host response should be mandatory reporting criteria for oral cavity squamous cell carcinoma: A re-look at the American joint committee of cancer (AJJCC) minimum dataset”. Indian Journal of Pathology and Microbiology4 (2020): 527-533.
  3. Shimizu S., et al. “Tumor budding is an independent prognostic marker in early-stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion”. PLoS ONE4 (2018): e0195451.
  4. Bin Xu., et al. “The prognostic role of histologic grade, worst pattern of invasion, and tumour budding in early oral tongue squamous cell carcinoma a comparative study”. Virchows Archiv3 (2021): 597-606.
  5. Yamamoto E., et al. “Mode of invasion, bleomycin sensitivity, and clinical course in squamous cell carcinoma of the oral cavity”. Cancer12 (1983): 2175-2180.
  6. Jakobsson PA., et al. “Histologic classification and grading of malignancy in carcinoma of the larynx”. Acta Radiology1 (1973): 1-7.
  7. Alhadi Almangush., et al. “Tumour budding in oral squamous cell carcinoma: a meta-analysis”. British Journal of Cancer 4 (2018): 577-586.


Citation: Amith KP., et al. “Tumour Budding - A Prognostic Indicator in Oral Squamous Cell Carcinoma?”. Acta Scientific Dental Sciences 6.10 (2022): 06-07.


Copyright: © 2022 Amith KP., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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