Nimmi Janardhanan¹, Sayana Nazrine¹ and Shivaprasad BM²*

¹Postgraduate Student, Department of Periodontology, Rajarajeswari Dental College and Hospital, Bangalore, India
²a. Implantologist, Tooth Priority: The Family Dental Care, Bangalore and b. Professor, Department of Periodontology, Rajarajeswari Dental College and Hospital, Bangalore, India

*Corresponding Author: Shivaprasad BM, a. Implantologist, Tooth Priority: The Family Dental Care, Bangalore and b. Professor, Department of Periodontology, Rajarajeswari Dental College and Hospital, Bangalore, India.

Received: February 28, 2022; Published: April 07, 2022.

Abstract

Platelets are small cells that circulate in blood playing an important role in managing hemostasis and vascular integrity. They are also known to release several growth factors which stimulate tissue regeneration. The ability of platelet concentrates (PC) to achieve the goals of tissue regeneration has been explored in sports medicine, orthopedics and maxillofacial surgeries. The use of PC in the treatment of periodontal or bone defects is a much more natural approach compared to other modalities such as guided tissue and bone regeneration. Currently platelet concentrates are utilized in various regenerative and rehabilitative surgeries such as perio-plastic surgeries, ridge preservation and implant surgeries. Platelet concentrates have the ability to harness body’s own growth factors and utilize it for regeneration. It is a trialed and proven fact that they can dramatically increase the treatment results in a beneficial manner.

Keywords: Platelet Concentrates; Regeneration; Dentistry; Medicine

References

1. Gasling VLW., et al. “Platelet-rich plasma and platelet-rich fibrin in human cell culture”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology Endodontics 108 (2009): 45-48.
2. Sohn DS., et al. “Utilization of autologous concentrated growth factors (CGF) enriched bone graft matrix (Sticky bone) and CGF-enriched fibrin membrane in Implant Dentistry”. Journal of Implant and Advanced Clinical Dentistry 7 (2015): 11-29.
3. Abdulgani Azzaldeen., et al. “Platelet-rich fibrin (PRF) in dentistry”. International Journal of Applied Dental Sciences4 (2019): 01-08.
4. Newman MG., et al. “Carranza's. Clinical Periodontology” (2015).
5. Agrawal AA. “Evolution, current status and advances in application of platelet concentrate in periodontics and implantology”. World Journal of Clinical Cases 5 (2017): 159-171.
6. Andrea Caruana., et al. “From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery”. European Journal of Dentistry2 (2019): 280-286.
7. Mijiritsky E., et al. “Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review”. Biology 2021, 10 (2021): 317.
8. Bansal S., et al. “Platelet-rich fibrin or platelet-rich plasma - Which one is better? An opinion”. Indian Journal of Dental Sciences 9 (2017): S49-52.
9. Megha Agrawal and Vineet Agrawal. “Platelet Rich Fibrin and its Applications in Dentistry- A Review Article”. National Journal of Medical and Dental Research3 (2014): 51-58.
10. Pradeep AR., et al. “Platelet-Rich Fibrin Combined with a Porous Hydroxyapatite Graft for the Treatment of 3-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial”. Journal of Periodontology12 (2017): 1288- 1296.
11. Hauser F., et al. “Clinical and histological evaluation of postextraction platelet-rich fibrin socket filling: a prospective randomized controlled study”. Implant Dentistry 22 (2013): 295-303.
12. Pan J., et al. “Effect of platelet-rich fibrin on alveolar ridge preservation: A systematic review”. Journal of the American Dental Association 9 (2019): 766-778.
13. Anilkumar K., et al. “Platelet-rich-fibrin: A novel root coverage approach”. Journal of Indian Society of Periodontology 1 (2009): 50-54.
14. Öncu E and Alaaddinoglu EE. “The effect of platelet-rich fibrin on implant stability”. The International Journal of Oral and Maxillofacial Implants 30 (2015): 578-582.
15. Boora P., et al. “Effect of Platelet Rich Fibrin (PRF) on peri-implant soft tissue and crestal bone in one-stage implant placement: a randomized controlled trial”. Journal of Clinical and Diagnostic Research 9 (2015): ZC18-ZC21.
16. Cortese A., et al. “Platelet-Rich Fibrin (PRF) in Implants Dentistry in Combination with New Bone Regenerative Flapless Technique: Evolution of the Technique and Final Results”. Open Medicine (Wars) 12 (2017): 24-32.
17. Choi BH., et al. “The use of autologous fibrin glue for closing sinus membrane perforations during sinus lifts”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Endodontics 101 (2006): 150-154.
18. Everts PA., et al. “Platelet-rich plasma and platelet gel: a review”. Journal of Extra-Corporeal Technology 2 (2006): 174-187.
19. Sanchez M., et al. “Comparison of surgically repaired Achilles’ tendon tears using platelet-rich fibrin matrices”. The American Journal of Sports Medicine 2 (2007): 245-251.
20. Arora R and Shukla S. “Injectable-Platelet-Rich Fibrin-Smart Blood with Stem Cells for the Treatment of Alopecia: A Report of Three Patients”. International Journal of Trichology 3 (2019): 128-131.
21. O’Connell B., et al. “The use of PRP injections in the management of knee osteoarthritis”. Cell and Tissue Research 376 (2019): 143-152.

Citation

Citation: Shivaprasad BM., et al. “The Journey of Platelet Concentrates: An Era of Regeneration in Medicine and Dentistry: A Review". Acta Scientific Dental Sciences 6.5 (2022): 03-10.

Copyright

Copyright: © 2022 Shivaprasad BM., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.