Acta Scientific Dental Sciences (ISSN: 2581-4893)

Research ArticleVolume 5 Issue 9

Cytotoxicity and Physicochemical Properties of a Promising Root Canal Sealer with Bioinductive Property

Fabrício Kitazono de Carvalho1, Fernanda Vicioni-Marques1, Marília Pacífico Lucisano1*, Bárbara Maria Garbelotti Fortunato1, Patrícia Maria Gatón-Hernández2, Paulo Nelson-Filho1, Raquel Assed Bezerra da Silva1 and Léa Assed Bezerra da Silva1

1Department of Pediatric Dentistry, University of São Paulo, School of Dentistry of Ribeirão Preto, Ribeirão Preto, Brazil
2Department of Pediatric Dentistry, University of Barcelona, School of Dentistry, Barcelona, Spain

*Corresponding Author: Marília Pacífico Lucisano, Department of Pediatric Dentistry, University of São Paulo, School of Dentistry of Ribeirão Preto, Ribeirão Preto, Brazil.

Received: July 27, 2021; Published: : August 26, 2021

Citation: Marília Pacífico Lucisano., et al. “Cytotoxicity and Physicochemical Properties of a Promising Root Canal Sealer with Bioinductive Property". Acta Scientific Dental Sciences 5.9 (2021): 135-142.


  The present study evaluated the physicochemical properties and cytotoxicity of AH Plus®, BioRoot RCS®, Endomethasone N® and Sealapex®. The working and setting time, radiopacity, flow and dimensional change were analyzed. Primary cells of human peripheral lymphocytes and MTT assay were used for cell viability evaluation. The results were analyzed by One-way ANOVA and Tukey's post-test (α = 5%). The longer working time was expressed by Endomethasone. AH Plus showed the longer setting time of 1450 minutes and Sealapex did not take prey. All materials exhibited acceptable radiopacity and flow properties. Regarding dimensional change, Sealapex® did not expressed results and Endomethasone, BioRoot and AH Plus had values in percentage of 1,269, 1,170 and 1,135, respectively. Endomethasone presented the worst cell viability and AH Plus and BioRoot did not express cytotoxicity (p > 0.05). BioRoot presents compatible properties to the human body cells and physicochemical properties within the ANSI/ADA parameters.

Keywords: Cytotoxicity; Endodontics; Physicochemical Analysis; Root Canal Filling Materials; Root Canal Obturation


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Copyright: © 2021 Marília Pacífico Lucisano., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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