Abstract

The sixth most common cancer diagnosed worldwide are head and neck cancer (HNC). In 2008, 633,000 new cases were diagnosed out of which 355,000 cases resulted in mortality. Early detection of precancerous lesions remains a challenge to clinicians. In 1983, evidence of Human Papilloma Virus (HPV) infection was identified in a subset of oropharyngeal carcinomas (OPC). Thus, confirming HPV as a causative agent in HNC. HPV is now recognized as an important risk factor for the development of oropharyngeal cancers, and results of previous studies have demonstrated epidemiological and molecular evidence of the presence of the HPV genome in pre-malignant oral lesions in SCC tissues, especially of the subtypes of HPV-16 and -18. There is close to no evidence linking HPV to carcinoma. However, this review focuses on the role of HPV in oral oncology and to comment on the HPV DNA reported frequencies potentially malignant oral lesions.

Keywords: Human Papilloma Virus (HPV); Malignant Lesion; Malignancy

References

1. Bouda M., et al. ““High risk” HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa”. Modern Pathology6 (2000): 644.
2. Götz C., et al. “Detection of HPV infection in head and neck cancers: promise and pitfalls in the last ten years: A Meta-Analysis”. Molecular and Clinical Oncology 10 (2019): 17-28.
3. Mosmann JP., et al. “Sexually transmitted infections in oral cavity lesions: Human papillomavirus, Chlamydia trachomatis, and Herpes simplex virus”. Journal of Oral Microbiology1 (2019): 1632129.
4. Campisi G., et al. “Human papillomavirus: Its identikit and controversial role in oral oncogenesis, premalignant and malignant lesions”. International Journal of Oncology4 (2007): 813-823.
5. World Health Organization. Human papillomavirus laboratory manual. Geneva: World Health Organization (2010).
6. Chaudhary AK., et al. “Role of human papillomavirus and its detection in potentially malignant and malignant head and neck lesions: updated review”. Head and Neck Oncology1 (2009): 22.
7. Syrjänen S. “Oral manifestations of human papillomavirus infections”. European Journal of Oral Science 126 (2018): 49-66.
8. Peterson CE., et al. “Society of Behavioral Medicine position statement: Society of Behavioral Medicine supports oral cancer early detection by all healthcare providers”. Translational Behavioral Medicine (2018).
9. Ferreira LL., et al. “Plasma HPV DNA is detectable in oral leukoplakia patients”. Pathology-Research and Practice7 (2017): 759-765.
10. https://www.genome.gov/
11. Kerishnan JP., et al. “Detection of human papillomavirus 16-Specific IgG and IgM antibodies in patient sera: A potential indicator of oral squamous cell carcinoma risk factor”. International Journal Of Medical Sciences6 (2016): 424.
12. Mesher D., et al. “HPV serology testing confirms high HPV immunisation coverage in England”. Plos One3 (2016): e0150107.

Citation

Citation: Paramita Ingle., et al. “Role of Human Papilloma Virus (HPV) in Potentially Malignant and Malignant Lesions of Head and Neck".Acta Scientific Dental Sciences 4.8 (2020): 52-57.

Copyright

Copyright: © 2020 Paramita Ingle., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.