Acta Scientific Clinical Case Reports (ASCR)

Case Report Volume 6 Issue 9

Unraveling the Intricacies of Acute Respiratory Distress Syndrome in Metastatic Parathyroid Carcinoma After Laser lung Metastatectomy

Soumi Pathak* and Mamta Dubey

Department of Anaesthesia, Rajiv Gandhi Cancer Institute and Research Centre, India

*Corresponding Author: Soumi Pathak, Department of Anaesthesia, Rajiv Gandhi Cancer Institute and Research Centre, India.

Received: August 18, 2025; Published: August 28, 2025

Abstract

Acute respiratory distress syndrome (ARDS) is a rare complication of hypercalcemia resulting from a parathyroid crisis, usually associated with acute kidney injury (AKI). The lack of familiarity with this condition can lead to uncertainty in management, ultimately resulting in severe and fatal outcomes. We are presenting a case of a 50-year-old female who had developed severe hypercalcemia and acute kidney injury (AKI) due to parathyroid carcinoma. Alarmingly, she deteriorated rapidly in the postoperative period after undergoing parathyroidectomy and lung laser metastectomy. She developed acute respiratory distress syndrome (ARDS) on postoperative day 2 with no evidence of cardiogenic pulmonary oedema or fluid overload. Importantly, all infection screenings sent multiple times returned negative. This case highlights the importance of awareness of the complications associated with parathyroid carcinoma and prompt intervention in managing these interconnected conditions.

Keywords: Acute Respiratory Distress Syndrome; Acute Kidney Injury; Hypercalcemia; Parathyroid Carcinoma; Parathyroidectomy

References

  1. Ullah A., et al. “Parathyroid Carcinoma: Incidence, Survival Analysis, and Management: A Study from the SEER Database and Insights into Future Therapeutic Perspectives”. Cancers (Basel)6 (2022): 1426.
  2. Spartalis E., et al. “Intraoperative Indocyanine Green (ICG) Angiography for the Identification of the Parathyroid Glands: Current Evidence and Future Perspectives”. In Vivo1 (2020): 23-32.
  3. Chow S., et al. “Parathyroid storm: rare manifestation of primary hyperparathyroidism”. CMAJ 134 (1986): 503-504. 
  4. Ahmad S., et al. “Hypercalcemic crisis: a clinical review”. The American Journal of Medicine 128 (2015): 239-245. 
  5. Hsu YH and Chen HI Acute respiratory distress syndrome associated with hypercalcemia without parathyroid disorders”. Chinese Journal of Physiology 51 (2008): 414-418. 
  6. Holmes F., et al. “Pulmonary oedema in hypercalcaemic crisis”. Lancet 303 (1974): 311-312.
  7. Mert M., et al. “A hyperparathyroid case with pulmonary edema: can hypercalcemia trigger pulmonary edema?” American Journal of Emergency Medicine 30 (2012): 512.
  8. Chen HI., et al. “The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs”. Journal of Biomedical Science 15 (2008): 227-238.
  9. Ueno K., et al. “Fulminant respiratory failure due to progressive metastatic pulmonary calcification with no predisposing factors after successful renal transplantation: A case report”. Pediatric Transplant8 (2016): 1152-1156.
  10. Liang Z., et al. “Metastatic pulmonary calcification misdiagnosed as a fungal infection: A case report”. Molecular and Clinical Oncology 3 (2016): 409-412.
  11. Sun HM., et al. “Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review”. Diagnostic Pathology 1 (2017): 38.
  12. Phitayakorn R and McHenry CR. “Hyperparathyroid crisis: Use of bisphosphonates as a bridge to parathyroidectomy”. Journal of the American College of Surgeons 206 (2008): 1106-1115.
  13. M Nakamura., et al. “Adult T-cell leukemia with hypercalcemia-induced metastatic calcification in the lungs due to production of parathyroid hormone-related protein”. Internal Medicine Tokyo Japan 40 (2001): 409-413.
  14. SA Peter and JF Cervantes. “Hypercalcemia associated with adult T-cell leukemia/lymphoma (ATL)”. Journal of the National Medical Association 87 (1995): 746-748.

Citation

Citation: Soumi Pathak and Mamta Dubey. “Unraveling the Intricacies of Acute Respiratory Distress Syndrome in Metastatic Parathyroid Carcinoma After Laser lung Metastatectomy". Acta Scientific Clinical Case Reports 6.9 (2025): 15-18.

Copyright

Copyright: © 2025 Soumi Pathak and Mamta Dubey. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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