Maria do Carmo Girão^1,2*, João Pedro Aniceto^1,3, Luís Galindo¹, Nelson Silva¹, Ricardo Girão¹ and Carlos Vaz¹

¹ General Surgery, Hospital CUF Tejo, Lisbon, Portugal
² General Surgery, Unidade Local de Saúde do Baixo Alentejo, Beja, Portugal
³ General Surgery, Hospital das Forças Armadas, Lisbon, Portugal

*Corresponding Author: Maria do Carmo Girão, General Surgery, Hospital CUF Tejo, Lisbon, Portugal.

Received: November 28, 2024; Published: December 18, 2024

Abstract

Gastric amyloidosis is a rare, localized form of amyloidosis that presents with non-specific gastrointestinal symptoms, often mimicking other conditions. A 56-year-old woman presented with dyspeptic symptoms, including postprandial bloating, heartburn, and weight loss. Endoscopy revealed nodular gastric lesions, and biopsies confirmed localized gastric amyloidosis (AL subtype) via Congo red staining. Systemic involvement was excluded. Despite initial symptom control with proton pump inhibitors, symptom recurrence and lesion progression led to a laparoscopic total gastrectomy. The patient had an uneventful recovery and remains asy mptomatic three months post-surgery. Gastric amyloidosis is exceedingly rare, with fewer than 35 cases reported over six decades. It predominantly presents with non-specific gastrointestinal symptoms, such as dyspepsia, hematemesis, or hematochezia, and lacks distinctive endoscopic features. Diagnosis relies on histological confirmation via Congo red staining and polarized light microscopy. Exclusion of systemic involve ment is critical for accurate disease classification and management. While systemic amyloidosis often requires chemotherapy, locali zed forms are best managed surgically, with favorable outcomes. This case highlights the diagnostic challenges of localized gastric amyloidosis and the importance of a multidisciplinary approach. Surgical management can offer excellent outcomes in this rare condition.