Mahesh Percy¹* and Ewarld Marshall²

¹Instructor/Medical Technologist, Medical Pathology Diagnostic Laboratory, St. George’s University, Grenada
²Chair, Pathology, Director Medical Pathology Diagnostic Lab, St. George’s University, Grenada

*Corresponding Author: Mahesh Percy, Instructor/Medical Technologist, Medical Pathology Diagnostic Laboratory, St. George’s University, Grenada.

Received: October 09, 2024; Published: December 09, 2025

Abstract

Multiple myeloma a plasma cell neoplasm typically presents with symptoms such as bone pain fatigue and weakness. It is a hemato logical malignancy characterized by the clonal proliferation of plasma cell in the bone marrow [1,2]. While the diagnosis of multiple myeloma is through bone marrow biopsy and serum protein electrophoresis [3], the presence of plasma cell in the peripheral blood smear is an uncommon finding [4]. The detection of rare plasma cell in the peripheral blood smear can provide critical diagnostic clues [5]. Here we present a case report of multiple myeloma in a 42 year old woman from Grenada in which plasma cell was identified in the peripheral blood smear.

Keywords: Myeloma; Plasma

References

1. Rajkumar S V and Kumar S. “Multiple myeloma: Diagnosis and treatment”. Mayo Clinic Proceedings1 (2016): 101-119.
2. Kyle R A and Rajkumar S V. “Multiple myeloma”. The New England Journal of Medicine18 (2004): 1860-1873.
3. Palumbo A and Anderson K. “Multiple myeloma”. The New England Journal of Medicine11 (2011): 1046-1060.
4. Kazandjian D. “Multiple myeloma epidemiology and survival: A unique malignancy”. Seminars in Oncology6 (2016): 676-681.
5. Rajkumar SV. “Multiple myeloma: 2020 update on diagnosis, risk-stratification, and management”. American Journal of Hematology5 (2020): 548-567.
6. Usmani SZ., et al. “Extraplanar myeloma: Clinicopathological and therapeutic perspectives”. Leukemia5 (2017): 986-995.
7. Fonseca R., et al. “International Myeloma Working Group molecular classification of multiple myeloma: Spotlight on risk stratification and implications for clinical management”. Leukemia12 (2009): 2210-2221.
8. Mateos M V and San Miguel JF. “Management of multiple myeloma in the newly diagnosed patient”. Hematology/Oncology Clinics of North America4 (2013): 859-873.
9. Landgren O and Rajkumar S V. “New developments in diagnosis, prognosis, and assessment of response in multiple myeloma”. Clinical Cancer Research22 (2016): 5428-5433.
10. Dimopoulos MA., et al. “Clinical characteristics of multiple myeloma patients with renal impairment: A systematic review of the literature”. The Lancet Oncology8 (2015): e375-e383.
11. Cavo M., et al. “International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation”. Blood23 (2011): 6063-6073.
12. Sonneveld P and Broijl A. “Treatment of relapsed and refractory multiple myeloma”. Hematology1 (2016): 508-517.
13. Avet-Loiseau H., et al. “Genetic abnormalities and survival in multiple myeloma: The experience of the IFM”. Blood8 (2007): 3489-3495.
14. Barlogie B., et al. “Curing myeloma at last: Defining criteria and providing the evidence”. Blood20 (2014): 3043-3051.
15. Mateos M V., et al. “Current approaches to the treatment of relapsed and refractory multiple myeloma”. Blood24 (2021): 2540-2554.
16. Morgan GJ., et al. “The genetic architecture of multiple myeloma”. Nature Reviews Cancer5 (2012): 335-348.
17. Paiva B., et al. “New criteria for response assessment: Role of minimal residual disease in multiple myeloma”. Blood 125.20 (2015): 3059-3068.

Citation

Citation: Mahesh Percy and Ewarld Marshall. “A Rare Peripheral Plasma Cell Finding in a Grenadian Woman with Multiple Myeloma: A Case Report". Acta Scientific Clinical Case Reports 6.1 (2025): 04-07.

Copyright

Copyright: © 2025 Mahesh Percy and Ewarld Marshall. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.