Acta Scientific Veterinary Sciences (ASVS)

Research Article Volume 2 Issue 2

Emamectin Benzoate - Induced Oxidative Stress, Heat Shock Protein Levels and Apoptotic Effects in the Brain of Male Mice

Özge Temiz*

Department of Biology, Cukurova University, Turkey

*Corresponding Author: Özge Temiz, Department of Biology, Cukurova University, Turkey.

Received: December 27, 2019; Published: January 07, 2020

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  Emamectin benzoate (EMB), which is used as a pesticide in veterinary medicine, can cause oxidative stress in living thing, and cell death as a result of its toxicity in tissues. In EMB doses; 25 mg/kg/day (E1), 50 mg/kg/day (E2), 100 mg/kg/day (E3) were administered by gavage to Swiss albino male mice for 14 days. Tripeptide glutathione (GSH), thiobarbituric acid reactive substance (TBARS) and stress protein levels and caspase 3 enzyme activity in brain tissue were examined. The results of the study showed that after exposure to EMB, it inhibited GSH and caused increased TBARS level. Increased levels of HSP70, one of the stress proteins, is an important mechanism that demonstrates that it cannot inhibit the increase in caspase 3 enzyme activity and that EMB toxicity triggers apoptosis. Changes in these molecular toxicology parameters, toxic effects of EMB are thought to be effective at 14 day exposure to brain tissue of male mice and cause neurotoxicity.

Keywords:Apoptosis; Brain; Heat Shock Proteins; Emamectin Benzoate; Mice

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Citation

Citation: Özge Temiz. “Emamectin Benzoate - Induced Oxidative Stress, Heat Shock Protein Levels and Apoptotic Effects in the Brain of Male Mice”. Acta Scientific Veterinary Sciences 2.2 (2020): 01-04.




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