Vikas Jakhmola^1,2, Sunil Jawla¹ and Ravinesh Mishra³*

¹Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India
²Department of Pharmacy, GRD (PG) IMT, Dehradun, Uttarakhand, India
³School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi (Solans), Himachal Pradesh, India

*Corresponding Author: Ravinesh Mishra, Associate Professor, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi (Solan), Himachal Pradesh, India.

Received: March 09, 2018; Published: April 03, 2018

Citation: Ravinesh Mishra., et al. “Synthesis, Characterization and Antihypertensive Activity of 4,5 Dihydropyridazin-3(2H)-One Derivatives”. Acta Scientific Pharmaceutical Sciences 2.5 (2018).

Abstract

  Some new 6-(substitutedphenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-phenyl substituted 2,3,4,5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (VJ1, VJ22) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity.

Keywords: β-Aroyl Propionic Acid; Pyridazinone; Antihypertensive Activity; Non-Invasive Method

Copyright: © 2018 Ravinesh Mishra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.