Acta Scientific Paediatrics (ISSN: 2581-883X)

Mini Review Volume 3 Issue 1

Pediatric Rotem Sigma Parameters in Potential Perioperative Hemorrhagic Surgery: An, Prospective Pilot Study Protocol Observational Prospective Pilot Study Protocol

Kumba C1-5* and Tréluyer JM3

1Department of Pediatric Anesthesia and Critical Care, Necker Enfants Malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, University of Paris, Paris, France

2Pediatric Cardiac and Congenital Heart Disease Intensive Care and Anesthesia Units, Necker Enfants Malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, University of Paris, Paris, France

3Department of Clinical Research and Pharmacology, Necker Enfants Malades-Cochin, University Hospitals, Assistance Publique Hôpitaux de Paris, Paris Descartes, University, University of Paris, Paris, France

4EA 7323 Pharmacologie et Evaluation des Thérapeutiques Chez L ‘Enfant et La Femme Enceinte, Université Paris Descartes, Université de Paris, Paris, France

5Ecole Doctorale 563 Médicaments-Toxicologie-Chimie-Imagerie MTCI, Université Paris Descartes, Université de Paris, Paris, France

*Corresponding Author: Kumba C, Department of Pediatric Anesthesia and Critical Care, Necker Enfants Malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Descartes University, University of Paris, Paris, France.

Received: December 09, 2019; Published: December 17, 2019

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Abstract

Background: A recent systematic review and meta-analysis was undertaken to determine the impact of transfusion goal directed protocols with viscoelastic methods on postoperative outcome in pediatric hemorrhagic surgery. This trial revealed that fresh frozen plasma transfusion and length of hospital stay were reduced in the group where transfusion was guided with point of care viscoelastic methods. A transfusion goal directed protocol with rotational thromboelastometry sigma is in preparation (ROTEM sigma). Since the actual. ROTEM parameters were determined with ROTEM delta, we would like to validate pediatric. parameters with ROTEM sigma. Once these parameters are validated in this trial they will be integrated in the pediatric transfusion protocol guided with ROTEM sigma in hemorrhagic surgery.

Objectives: The primary objective is to determine pediatric ROTEM sigma parameters predictive of intraoperative and postoperative transfusion. The secondary objectives are to determine pediatric ROTEM sigma parameters predictive of intraoperative and postoperative blood loss, postoperative length of intensive care stay (LOSICU), length of mechanical ventilation (LMV) and length of hospital stay (LOS).

Methods: Patients aged less than 18 years old admitted for potential hemorrhagic surgery. The study will be monocentric. Statistic analysis will be realized with XLSTAT 2018.3 or plus software.

Conclusion: This pilot study will determine pediatric ROTEM sigma parameters predcitive of intraoperative and postoperative transfusion, blood loss and postoperative LOSICU, LMV and LOS which will be integrated in a transfusion goal directed protocol guided with ROTEM sigma.

Keywords: Transfusion Goal Directed Protocol; ROTEM Sigma; Children; Outcome

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Citation

Citation: Kumba C and Tréluyer JM. "Pediatric Rotem Sigma Parameters in Potential Perioperative Hemorrhagic Surgery: An, Prospective Pilot Study Protocol Observational Prospective Pilot Study Protocol".Acta Scientific Paediatrics 4.1 (2020): 31-33.



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