Liaqat Ali¹*, Saleha Akram Nizami² and Hafiza Sobia Ramzan³

¹Associate Professor, Anatomy, Swat Medical College, Swat, Pakistan
²Working as a Senior Demonstrator in Al-Aleem Medical College, Pakistan
³Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan

*Corresponding Author: Liaqat Ali, Associate Professor, Anatomy, Swat Medical College, Swat, Pakistan.

Received: July 31, 2021; Published: September 18, 2021

Citation: Liaqat Ali., et al. “Cardiac Protective Activity of Ethanol Extract of White Curcumin (Curcuma Zedoaria), Against Cyclophosphamid Induced Cardiovascular Complications in Male Sprague Dewley Mice". Acta Scientific Medical Sciences 5.10 (2021): 82-91.

Abstract

  The common side effects associated with cyclophosphamide administration are bone marrow suppression, exposure to infections, amenorrhoea, toxic kidney poisoning and cystitis, as well as cardiovascular complications, including sinus bradycardia, pericarditis, myocarditis, and type 1 heart problems. A natural resource used as an alternative solution to reduce these unwanted effects, is Curcuma zedoaria, due to the presence of curcumin. This study therefore aims to determine the extent of protection of Curcuma zedoaria offers against cyclophosphamide in rat hearts, based on 4 indicators, CKMB enzymes, peripheral blood, troponin T and cardiac cell histopathology. The research was conducted using 30 rats divided into 6 groups, a normal group (without treatment), a negative control group (Na-CMC 0.5%), a positive control group (catechins), and 3 experimental groups administered white turmeric rhizome ethanol extract, in various doses. Each rats group was given 150 mg/kg of cyclophosphamide solution, 11 to 15 days before the experiment. The results showed the mice’s CKMB and troponin T, and leukocyte levels decreased with increasing doses of Curcuma zedoaria. In addition, the erythrocyte levels were within the normal range in each group except the negative group, while the platelet levels were all within the normal range except for the negative group and the 200mg/kgbb turmeric dose group. Meanwhile, the lymphocyte levels in each group were within the normal range. The histopathological picture shows reduction in cariorexis and caryolysis features with increasing doses, especially in the group administered with 800 mg/kgbb dosage. However, all experimental groups were discovered to suffer from active inflammation. Therefore, Curcuma Zedoaria was concluded to exhibit partial protective activity against the effects of cyclophosphamide overexposure in mice.

Keywords: Curcuma Zedoaria; Cyclophosphamide; Curcumin; CKMB; Troponin T; Blood Examination and Histopathology

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Copyright: © 2021 Liaqat Ali., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.