Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Editorial Volume 3 Issue 2

The Challenge of Evaluation of Gastrointestinal Symptoms in HIV Patients

Stefani Panayiotou*

Department of Gastroenterology and Hepatology, University of Cyprus, Athens, Greece

*Corresponding Author: Stefani Panayiotou, Department of Gastroenterology and Hepatology, University of Cyprus, Athens, Greece.

Received: November 26, 2019; Published: January 01, 2020

×

  HIV disease is a frequent infection, whose number of individuals living with it worldwide exceeds 37 million [1]. Among the lots of complications which it causes are gastrointestinal and hepatobiliary disorders [2]. More than 50% of all HIV patients had reported gastrointestinal (GI) symptoms during their disease [3,4].

  HIV and gastrointestinal system appears to have a relation. The gastrointestinal tract has a primary role in pathogenesis of HIV infection [5]. Studies have shown that GI system is a main site of HIV replication and CD4 T-cell death [6]. During the infection there is considerable reduction of CD4 T-cells within the gut-associated lymphoid tissue (GALT) [7].

×

References

  1. Global HIV and AIDS statistics — 2019 fact sheet. UNAIDS (2019).
  2. Koch J., et al. “Gastrointestinal Manifestations of HIV”. HIV InSite Knowledge Base Chapter (1998).
  3. Malenbranche R., et al. “Acquired immunodeficiency syndrome with severe gastrointestinal manifestations in Haiti”. Lancet 2 (1983): 873-878.
  4. Gazzard BG. “HIV disease and the gastroenterologist”. Gut 29 (1988): 1497-1505.
  5. Knox TA., et al. “Diarrhea and abnormalities of gastrointestinal function in a cohort of men and women with HIV infection”. The American Journal of Gastroenterology 95 (2000): 3482-3489.
  6. Nannini EC and Okhuysen PC. “HIV1 and the gut in the era of highly active antiretroviral therapy”. Current Gastroenterology Reports 4 (2002): 392-398.
  7. Veazey RS., et al. “Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection”. Science 280 (1998): 427-431.
  8. Wilcox CM., et al. “AGA Technical Review: Malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection”. Gastroenterology 111 (1996): 1724-1752.
  9. Dworkin B., et al. “Gastrointestinal manifestations of the acquired immunodeficiency syndrome: A review of 22 cases”. The American Journal of Gastroenterology 80 (1985): 774-778.
  10. Gallant JE., et al. “Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine”. Journal of Infection Disease 166 (1992): 1223-1227.
  11. Nightingale SD., et al. “Incidence of Mycobacterium avium-intracellulare complex bacteremia in human immune deficiency virus-positive patients”. Journal of Infection Disease 165 (1992): 1082-1085.
  12. Janoff EN and Smith PD. “Perspectives on gastrointestinal infections in AIDS”. Gastroenterology Clinics of North America 17 (1988): 451-463.
  13. Ulrich R., et al. “AIDS enteropathy”. Annals of Internal Medicine 115 (1991): 328.
  14. Kotler DP., et al. “Enteropathy associated with the acquired immunodeficiency syndrome”. Annals of Internal Medicine 101 (1984): 421-428.
  15. Kotler DP. “HIV infection and the gastrointestinal tract”. AIDS 19 (2005): 107-117. 
  16. Maresca M., et al. “The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line”. Journal of Biomedical Science 10 (2003): 156-166.
  17. Schmitz H., et al. “Supernatants of HIV-infected immune cells affect the barrier function of human HT-29/B6 intestinal epithelial cells”. AIDS 16 (2002): 983-991.
  18. Ulrich R., et al. “Enteric immunologic abnormalities in human immunodeficiency virus infection”. Seminar on Liver Disease 12 (1992): 167-174.
  19. Riecken EO., et al. “Non-opportunistic causes of diarrhoea in HIV infection”. In: Gazzard BG, ed. Bailliere's Clinical Gastroenterology. London: Balliere-Tindall 4 (1990): 385-403.
  20. Foucar E., et al. “Colon ulceration in lethal cytomegalovirus infection”. American Journal of Clinical Pathology 76 (1981): 788-801.
  21. Meiselman MS., et al. “Cytomegalovirus colitis: Report of the clinical, endoscopic and pathologic findings in two patients with acquired immunodeficiency syndrome”. Gastroenterology 88 (1985): 171-175.
  22. Eras P., et al. “Candida infection of the gastrointestinal tract”. Medicine 51 (1972): 367-379.
  23. Cello JP and Wilcox CM. “Evaluation and treatment of gastrointestinal tract hemorrhage in patients with AIDS”. Gastroenterology Clinics of North America 17 (1988): 639-648.
  24. Kotler DP., et al. “Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis”. AIDS 12 (1998): 597-604.
  25. He M., et al. “Prospective observation for seven-year’s highly active antiretroviral therapy in Chinese HIV-1 Infected patients”. Current HIV Research 9 (2011): 160-165.
  26. Wallace MR and Brann OS. “Gastrointestinal manifestations of HIV infection”. Current Gastroenterology Reports 2 (2000): 283-293.
  27. Tadesse WT., et al. “Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV-infected patients: a cross-sectional study”. BMC Pharmacology and Toxicology 15 (2014): 32.
×

Citation

Citation: Stefani Panayiotou. "The Challenge of Evaluation of Gastrointestinal Symptoms in HIV Patients".Acta Scientific Gastrointestinal Disorders 4.2 (2020): 01-03.



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for March Issue
    The last date for submission of articles for regular Issues is March 10, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US